Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer.

نویسندگان

  • Minkyu Kim
  • Manos Gkikas
  • Aaron Huang
  • Jeon Woong Kang
  • Nisaraporn Suthiwangcharoen
  • Ramanathan Nagarajan
  • Bradley D Olsen
چکیده

A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.

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عنوان ژورنال:
  • Chemical communications

دوره 50 40  شماره 

صفحات  -

تاریخ انتشار 2014